CrystalsFirst offers expert co-crystallization services to obtain high-resolution protein–ligand structures that drive structure-based drug design. Our structural biologists excel at crystallizing challenging targets with bound small molecules, leveraging both traditional co-crystallization and advanced soaking approaches to increase the occupancy of bound ligands in co-crystals.
By obtaining detailed 3D co-structures early in discovery, we empower medicinal chemists with precise atomic insights for rational design. Each co-crystal structure reveals key binding interactions and conformational changes, directly guiding lead optimization. CrystalsFirst’s track record as an expert in protein crystallization and structure determination underscores our ability to overcome bottlenecks in drug discovery.
Whether your program requires de novo co-crystallization or iterative structure determination for fragments, lead compounds or biologics, our team provides a reliable, fast-turnaround pipeline.