High-performance crystallography platform
Our labs and offices are located directly at Germany’s largest accelerator DESY in Hamburg. CrystalsFirst has regular access to the high-end synchrotron facility and can provide services for data collection. The unmatched hands-on expertise of our team encompasses experience of data collection at different synchrotron facilities across Europe.
CrystalsFirst can also perform synchrotron measurements at BESSY (Berlin, Germany), SLS (Villigen, Switzerland), ALBA (Barcelona, Spain), MAX IV (Lund, Sweden) as well as ESRF (Grenoble, France).
We offer stand-alone service packages for high-quality manual structure refinements. In the fragment-based drug discovery, CrystalsFirst can analyze the data and propose binders for structure refinement. Selection criteria will be based on the nature and extent of the potential interaction network of the ligand and the binding site, the ligand structure and the nature of the binding site.
Our experience in refinements includes a wide range of protein families as well as non-covalent and covalent modalities.
We have complete licenses to state-of-the art software packages for macromolecular crystallography and structure determination — Phenix, CCP4, XDSAPP for macromolecular crystallography and structure determination.
Fast and secure data transfer and the management of X-ray crystallography data, is an integral part of our core capabilities.