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COMPUTATIONAL MODELING DRIVES SELECTIVITY OF CRL4 CRBN RECRUITING PROTACs

  • Selectivity is still a major challenge in the design of CRL4CRBN recruiting PROTACs. 
  • Prediction of key interactions mediating the formation of productive ternary complexes can overcome the selectivity issues. 
  • Using structural insights from known neo-substrates, degron blocking design principles, and computational modelling lead to an analogue with an improved selectivity profile. 

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