CrystalsFirst

THE SMARTSOAK® ADVANTAGE FOR COVALENT DRUG DISCOVERY

SmartSoak provides significant advantages for for covalent fragment-based drug discovery enabling rapid determination of co-structures for optimization: 

  • Conventional soaking fails to modify the cysteine in the active site
  • SmartSoak setup enables the covalent modification of cysteine
  • High resolution co-structure of human protein with novel MOA at 1.3 Å

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