THE SMARTSOAK® ADVANTAGE FOR COVALENT DRUG DISCOVERY

SmartSoak® provides significant advantages for covalent fragment-based drug discovery enabling rapid determination of co-structures for optimization: 

• Conventional soaking fails to modify the cysteine in the active site
• SmartSoak setup enables the covalent modification of cysteine
• High resolution co-structure of human protein with novel MOA at 1.3 Å